Protein misfolding events has over the past 20 years been associated with the pathogenesis of multiple diseases, ranging from diseases of genetic origins (Cystic Fibrosis/1-alpha antitrypsin deficiency) to metabolic disorders (Diabetes) and cancer. We are interested to learn more about the molecular events that occurs when proteins are not folded correctly in the endoplasmic reticulum (ER) and to elucidate the downstream activation of the Unfolded Protein Response (UPR) to clarify its possible role in the initiation and progression of chronic lung disorders. We believe that increased understanding of the molecular pathwas involved in the response to cellular ER stress and protein misfolding events will enable us to identify novel molecular targets involved in both disease initiation and progression.
This day-in-the-life video serves to demystify aspects of the Ask Lab at McMaster University by following a student's typical day in the lab! The Ask Lab explores protein misfolding events, which have contributed to the development of various diseases such as cystic fibrosis, diabetes, and cancer. This lab is mainly interested in the events in the endoplasmic reticulum (ER) which occur when proteins do not fold correctly. The Unfolded Protein Response (UPR) is discussed, which may play a role in the development and further progression of chronic lung diseases. In addition, the video covers what fibrosis is and how we can test that in the lab, as well as the clinical implications. This video features a talk from a PhD student Ehab Ayaub, a Masters candidate Sohail Mahmood, and principal investigator Dr. Kjetil Ask.
This video was created by Health Science 4DM3 students: Mawleshan Pathmajarah, Hassan Alsaleh, Dana Abu-Jazar, Aunima Bhuiya, and Hina Abdulla. Please let us know waht you think about this video here.
Ayaub EA, Kolb PS, Mohammed-ali Z, Tat V, Murphy J, Bellaye PS, Shimbori C, Boivin FJ, Lai R, Lynn EG, Lhotak S, Bridgewater D, Kolb MRJ, Inman MD, Dickhout JG, Austin RC and Ask K. GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis. Journal of Pathology. http://www.ncbi.nlm.nih.gov/pubmed/27135434